Chemoenzymatic acylation of aminoglycoside antibiotics
2008
The chemoenzymatic installation of the clinically valuable (S)-4-amino-2-hydroxybutyryl side chain onto a number of 2-deoxystreptamine-containing aminoglycosides is described using the purified Bacillus circulans biosynthetic enzymes BtrH and BtrG in combination with a synthetic acyl-SNAC surrogate substrate.
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Bibliographic information
Chemical communications
Issue
32
Pagination
3786
- 3788
ISSN
1364-548X
Publisher
American Association for the Advancement of Science
Other Subjects
Chemical communication; Aminoglycoside antibiotics; Aminoglycosides
Language
English
Type
Journal Article; Text
2024-02-28
MODS
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