RNA‐seq analysis of green tea polyphenols modulation of differently expressed genes in Enterococcus faecalis under low pH
2022
Enterococcus faecasslis (E. faecalis) is a resident bacterium in the host. The increase in internal stress like low pH may affect the biological effects of E. faecalis. The prebiotic‐like function of tea polyphenols can enhance the beneficial effects of its tolerance to environmental stress. In this study, RNA‐sequence analysis was used to explore the protective effect of green tea polyphenols (GTP) on E. faecalis under low pH stress. A total of 28 genes were found to be responsive to GTP under low pH stress, including 16 up‐regulated and 12 down‐regulated. GTP intervention can partly relieve some undesired negative influences, such as the down‐regulation of the base excision repair gene and amino acid transport and metabolism gene. The significantly changes were associated with selenocompound metabolism and aminoacyl‐tRNA biosynthesis after the intervention of GTP. The present study provided new insights into the growth and continuous adaptation of E. faecalis under stress.
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