New dammarane and ursane-type triterpenoids from the flower of Ixora coccinea Linn
2016
Ikram, Ambreen | Versiani, Muhammad Ali | Khatoon, Amna | Ahmed, Salman Khalid | Sattar, Samina Abdul | Faizi, Shaheen
Two new esters of dammarane triterpenoids ixorene isovalerate (1), ixorene 3′,8′-dimethyloctanoate (2) and a new ursane-type triterpenoids Ixoroid acid (3) were isolated from the methanolic extract of flowers of Ixora coccinea Linn., along with the three known constituents. The structures of compounds 1 and 3 were elucidated on the basis of extensive 1D,2D NMR studies and mass spectrometry as 17β-dammara-12,20-diene-3β-isovelarate and 3β-hydroxy-18β-urs-12ene-29β-oic acid, respectively, whereas 2 was identified as 17β-dammara-12,20-diene-3β-3′,8′-dimethyloctanoate through ¹H NMR and mass spectral data. Compounds 1 , 2 , 4 and 5 were evaluated for their in vitro cytotoxic activity, which exhibited weak activity against the 3T3, PC3 and HeLa cell lines with the IC ₅₀ value >30 μM. Antioxidant results of 1 – 5 revealed that only compound 5 showed antioxidant activity in DPPH radical scavenging inhibition with the IC ₅₀ 1.31 × 10 ⁻ ⁶ ± 0.005 μm mL ⁻ ¹. Both activities are the first records of these isolated compounds from the flowers of Ixora coccinea Linn.
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