Mycotoxins produced by Fusarium tricinctum as possible causes of cattle disease
1970
Fusarium tricinctum, which frequently occurs on tall fescue grass and on corn, produces 4-acetamido-4-hydroxy-2-butenoic acid γ-lactone and 4β,15-diacetoxy - 8α - (3 - methylbutyryloxy) - 12,13-epoxytrichothec-9-en-3α-ol (T-2 toxin) when grown on laboratory media. The acetamido lactone, prepared synthetically from 4-ethoxy-4-hydroxy-2-butenoic acid γ-lactone, was injected intramuscularly at 3.8 mg/kg into a heifer for 90 days and produced dry gangrene at the end of the tail. This lesion is one of the two most characteristic signs sometimes observed in cattle grazing on tall fescue grass. T-2 toxin, isolated from cultures of F. tricinctum grown on Sabouraud's agar, was injected at 0.1 mg/kg into a steer for 65 days and caused death from internal hemorrhaging similar to that occasionally found in cattle after ingestion of moldy corn.
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