Cytotoxic triterpenoid saponins from the root of Anemone tomentosa (Maxim.) Pei
2020
Zhang, Yu | Niu, Xueni | Jia, Yingchao | Lv, Chongning | Wang, Jing | Jia, Lingyun | Lu, Jincai
Two new triterpenoid saponins, tomentoside T₁ (1) and tomentoside T₂ (2), together with eleven known compounds (3–13) were obtained from ethyl acetate extracts of Anemone tomentosa (Maxim.) Pei by bioactivity-guided isolation. Their structures were elucidated by chemical and spectral analysis, including 1D, 2D NMR data and HRESIMS. The cytotoxic activity of all isolated saponins was evaluated on MDA-MB-231 and PC-3 cell lines. Compounds 5 and 7 showed significant cytotoxicity against with MDA-MB-231 cell and PC-3 cell with IC₅₀ values of 3.73–4.21 μM and 3.53–5.37 μM, respectively.
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