A fundamental dual regulatory role of citrate on the biosyntheses of thuringiensin and poly-β-hydroxybutyrate in Bacillus thuringiensis YBT-032
2007
Wang, Zhi | Chen, Shouwen | Sun, Ming | Yu, Ziniu
The production of α-ketoglutarate, adenine, thuringiensin production rate and thuringiensin yield on glucose consumed increased by 22%, 36%, 40% and 40%, respectively, in presence of 2 g citrate/l. However, citrate decreased pyruvate production, poly-β-hydroxybutyrate (PHB) production rate and PHB yield by 62%, 31% and 45%, respectively. The activities of pyruvate kinase and glucose-6-phosphate dehydrogenase were 36%–45% lower and 50%–120% higher than those of the control, respectively. The results suggest that citrate regulated the carbon flux to synthesis of adenine present in thuringiensin with a higher efficiency of utilization of glucose by decreasing PHB synthesis.
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