Antioxidant activities of methanol extracts of Curculigo pilosa rhizome and Gladilous psittascinus corm against lipid peroxidation in rat’s liver and heart
2019
Karigidi, Kayode Olayele | Ojebode, Mojisola Esther | Anjorin, Oluwasegun Joseph | Omiyale, Benjamin Olusola | Olaiya, Charles Ojo
Antioxidant activities of methanol extracts of the rhizome of Curculigo pilosa (CP) and corm of Gladiolus psittacinus (GP) were determined using 2,2-diphenyl-1-picrylhydrazyl (DPPH) scavenging effect, reducing power, total antioxidant capacity (TAC), total phenolics content (TPC), and total flavonoid content (TFC). Lipid peroxidation was induced by sodium nitroprusside (SNP) in the liver and heart of healthy Wistar albino rats (in vitro) and peroxidation was monitored by malondialdehyde (MDA) content. Phytochemical screening showed the presence of tannins, steroids, and flavonoids in CP rhizomes and saponins and cardiac glycosides in GP corms. The results showed that CP possessed higher TPC, TFC, and TAC than GP and higher DPPH scavenging and reducing power activities. CP and GP inhibited the production of MDA in SNP-incubated heart and liver homogenates in a dose-dependent manner. However, the methanol extracts of the CP rhizomes showed higher reduction in MDA content than the corms of GP.
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