The Effect of Fetal and Early Postnatal Iron Deficiency on Iron Metabolism in Adult Rats
2012
Fu, Jinyan | Yang, Anqiang | Ma, Yajing | Liu, Min | Zhang, Licui | Wang, Yong | Liu, Liegang
Undernutrition during pregnancy and/or lactation plays an important role on the overall health of offspring later in life. Using a rodent model, the present study was conducted to examine the effect of fetal and early postnatal iron deficiency on iron metabolism in adult animals. Rats were treated with three stages of low or normal iron diets from gestation until the end of the study. During the first stage (4 weeks prior to 3 weeks after pregnancy, total 7 weeks), two groups of adult females (dams) were fed with either a low-iron (7.4 mg iron/kg, group LD) or control-iron (274 mg/kg, group CD) diet. During the second stage (from 3 to 13 weeks of age, total 10 weeks), all pups from stage 1 (both the LD and CD groups) were placed on a control-iron diet for 10 weeks (groups LD–CD and CD–CD, respectively). During the third stage (from 13 to 29 weeks of age, total 16 weeks), both LD–CD and CD–CD groups from stage 2 were fed with a low-iron (named LD–CD–LD and CD–CD–LD groups, respectively). We found that the live birth rate of the offspring of the LD dams (84.7 %) was significantly lower than that of the CD dams (95.4 %). During stage 2, the mean body weight of the LD–CD male or LD–CD female rats exceeded the CD–CD male rats (p < 0.05). Compared with the CD–CD–LD rats, the LD–CD–LD rats had significantly increased total iron binding capacity, and higher levels of transferrin, serum erythropoietin (EPO), renal EPO mRNA, duodenal divalent metal transporter-1, and renal transferrin receptors. These findings indicate that rats with an early-life experience of iron deficiency (during pregnancy and the nursing period) can develop stronger iron absorption capabilities in adulthood.
Show more [+] Less [-]AGROVOC Keywords
Bibliographic information
This bibliographic record has been provided by National Agricultural Library