Cholesterol vehicle in experimental atherosclerosis. 20. Cottonseed oil and randomized cottonseed oil
1998
Kritchevsky, D. | Tepper, S.A. | Wright, S. | Kuksis, A. | Hughes, T.A.
Earlier studies have suggested that the presence of palmitic acid in the SN2 position of a triglyceride increases its atherogenic potential. Cottonseed oil contains about 24% palmitic acid of which only 2% is present at SN2. After randomization one third of the palmitic acid of cottonseed oil is at SN2. Rabbits were fed a semipurified diet containing 14% native or randomized cottonseed oil and 0.10% cholesterol. After 90 days the rabbits fed the randomized cottonseed oil exhibited significantly more severe atherosclerosis than those fed the native cottonseed oil. Plasma lipid levels were similar in the two groups. The increased atherogenicity of the randomized cottonseed oil may reflect the increased absorbability of fats with palmitic acid at the SN2 position.
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