Highly efficient chemoselective construction of 2,2-dimethyl-6-substituted 4-piperidones via multi-component tandem Mannich reaction in ionic liquids
2010
Feng, Li-Chun | Sun, Ya-Wei | Tang, Wei-Jun | Xu, Li-Jin | Lam, Kim-Lung | Zhou, Zhongyuan | Chan, Albert S. C.
The room temperature ionic liquid [bmim][PF₆] has been demonstrated to be an efficient and recyclable medium for highly chemoselective synthesis of 2,2-dimethyl-6-substituted 4-piperidones via a l-proline catalyzed tandem Mannich reaction of ammonia, aldehydes and acetone, and good yields were achieved for aryl and alkyl aldehydes.
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