The Castagnoli-Cushman reaction in a three-component format
2018
Chupakhin, Evgeny | Dar'in, Dmitry | Krasavin, Mikhail
The first example of the Castagnoli-Cushman reaction of homophthalic acid with an amine and an aldehyde conducted in a three-component format is reported. This new protocol employs no dehydrating agents and, unlike the traditional Castagnoli-Cushman reaction of homophthalic anhydride, allows simultaneous mixing of all three reagents and provides good to excellent yields of trans-configured tetrahydroisoquinolonic acids.
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