Experimental challenge of the freshwater fish pathogen Aeromonas hydrophila Ah17 and its effect on snakehead murrel Channa striata
2022
Vignesh, Samayanpaulraj | Krishnaveni, Govindaraj | Walter Devaa, J. C. | Muthukumar, Sivaramapillai | Uthandakalaipandian, Ramesh
Aeromonas hydrophila is an opportunistic bacterial fish pathogen causing huge economic losses in aquaculture farms. Present work explored the pathophysiological effects of experimental A. hydrophila Ah17 under sublethal dose (1 × 10⁵ CFU/ml, 500 μl) in Channa striata. Experiments revealed higher A. hydrophila Ah17 load in muscle tissue and lower in the kidney tissue. Haematological parameters and total serum protein level were significantly decreased in A. hydrophila Ah17 infected group when compared to the control group. Elevation of liver enzyme markers (AST, ALT and ALP) were noticed in infected group. Antioxidant genes (Cat, MnSOD and GPx) were highly expressed in liver tissue compared to the head kidney. Immune regulatory gene IL-8 was significantly downregulated and TGF-β was upregulated in head kidney and spleen tissues. Imbalanced swimming conditions, changes in pectoral fin movement, caudal fin injury, dorsal and ventral ulceration on body parts, haemorrhagic lesions and white foci in the liver were noticed during A. hydrophila Ah17 infection. Thus, the present study demonstrated the pathophysiological effects of A. hydrophila Ah17 against economically important snakehead murrel C. striata under sublethal conditions.
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