Polyacetylenes from Artemisia borealis and their biological activities
1990
Wang, Y. | Toyota, M. | Krause, F. | Hamburger, M. | Hostettmann, K.
From a dichloromethane extract of Artemisia borealis two polyacetylenes were isolated through activity guided fractionation. Their structures were established by spectroscopic and chemical methods. Complete assignments of the NMR spectra were obtained through extensive homonuclear spin decoupling and 2D homo- and heteronuclear correlation. The genuine polyacetylenes and their acetates exhibited antifungal activity. Heptadeca-1,9(Z),16-trien-4,6-diyn-3,8-diol was highly active in the brine shrimp assay and exhibited also larvicidal activity against the yellow ever mosquito Aedes aegypti.
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