Nasal lavages as a tool for monitoring exposure to organic pollutants
2019
Velázquez-Gómez, Miguel | Lacorte, Silvia
Exposure to air and dust pollutants can cause several adverse effects on human health. This study proposes the use of nasal lavages as a non-invasive sampling technique to determine in a direct way pollutant intake through inhalation. We evaluate the occurrence of compounds widely used in domestic products and construction materials (organophosphorus flame retardants (OPFR), phthalates, alkyphenols and bisphenol A), applied for pest control in cities (pesticides) and emitted through car exhausts (polycyclic aromatic hydrocarbons, PAHs) or smoking (nicotine). Contaminants were liquid-liquid extracted from nasal lavages and analysed using gas chromatography coupled to tandem mass spectrometry (GC-MS/MS). All 29 individuals inhabiting in Barcelona city had phthalates and bisphenol A at concentrations up to 31,300 ng mL−1 for diethylhexyl phthalate (DEHP) and 118 ng mL−1 for BPA. Individual PAHs, OPFR and alkylphenols had median values below their MQLs except for 2-ethylhexyldiphenyl phosphate (EHDPhP) with a median of 1.47 ng mL−1. Nicotine was detected at the highest concentrations in all active smokers (median 2.16 ng mL−1). Contrarily, pesticides were sporadically detected. Nasal lavages revealed to be an appropriate indicator likely to reflect exposure to dust and air contaminants.
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