Fish oil blunts lung function decrements induced by acute exposure to ozone in young healthy adults: A randomized trial
2022
Chen, Hao | Tong, Haiyan | Shen, Wan | Montilla, Tracey S. | Case, Martin W. | Almond, Martha A. | Wells, Heather B. | Alexis, Neil E. | Peden, David B. | Rappold, Ana G. | Diaz-Sanchez, David | Devlin, Robert B. | Bromberg, P. A. (Philip A.) | Samet, James M
Over one-third of the U.S. population is exposed to unsafe levels of ozone (O₃). Dietary supplementation with fish oil (FO) or olive oil (OO) has shown protection against other air pollutants. This study evaluates potential cardiopulmonary benefits of FO or OO supplementation against acute O₃ exposure in young healthy adults. Forty-three participants (26 ± 4 years old; 47% female) were randomized to receive 3 g/day of FO, 3 g/day OO, or no supplementation (CTL) for 4 weeks prior to undergoing 2-hour exposures to filtered air and 300 ppb O₃ with intermittent exercise on two consecutive days. Outcome measurements included spirometry, sputum neutrophil percentage, blood markers of inflammation, tissue injury and coagulation, vascular function, and heart rate variability. The effects of dietary supplementation and O₃ on these outcomes were evaluated with linear mixed-effect models. Compared with filtered air, O₃ exposure decreased FVC, FEV₁, and FEV₁/FVC immediately post exposure regardless of supplementation status. Relative to that in the CTL group, the lung function response to O₃ exposure in the FO group was blunted, as evidenced by O₃-induced decreases in FEV₁ (Normalized CTL −0.40 ± 0.34 L, Normalized FO −0.21 ± 0.27 L) and FEV₁/FVC (Normalized CTL −4.67 ± 5.0 %, Normalized FO −1.4 ± 3.18 %) values that were on average 48% and 70% smaller, respectively. Inflammatory responses measured in the sputum immediately post O₃ exposure were not different among the three supplementation groups. Systolic blood pressure elevations 20-h post O₃ exposure were blunted by OO supplementation. FO supplementation appears to offer protective effects against lung function decrements caused by acute O₃ exposure in healthy adults.
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