Body lipids of guinea pigs exposed to different dietary fats from mid-gestation to 3 months of age. V. The fatty acid composition of brain lipids at birth
1980
Pavey, Diana E. | Widdowson, Elsie M.
The fatty acid composition of the brain lipids of neonatal guinea pigs was affected by the type and amount of maternal dietary fat consumed by their mothers during late gestation. Pregnant animals were fed a commercial low-fat diet, or a high-fat diet containing either beef drippings or corn oil. Brain lipids of the newborn offspring were analyzed for fatty acid content of the 2 main phospholipid classes, phosphatidylcholine and phosphatidylethanolamine, by gas chromatography. Brains of guinea pigs born to mothers fed corn oil during pregnancy contained higher percentages of linoleic, arachidonic and docosapentaenoic acids, and lower percentages of docosahexaenoic acid, than did brains of offspring of mothers fed the other diets. Changes occurred mostly in long-chain polyunsaturated fatty acid derivatives. These data suggest that differences in fatty acid composition of the brain may also occur in human infants as a result of dietary manipulations in the fat contents of infant formulas.
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