Expression of a family of noncoding mitochondrial RNAs distinguishes normal from cancer cells
2009
Burzio, Verónica A. | Villota, Claudio | Villegas, Jaime | Landerer, Eduardo | Boccardo, Enrique | Villa, Luisa L. | Martínez, Ronny | Lopez, Constanza | Gaete, Fancy | Toro, Viviana | Rodríguez, Ximena | Burzio, Luis O.
We reported the presence in human cells of a noncoding mitochondrial RNA that contains an inverted repeat (IR) of 815 nucleotides (nt) covalently linked to the 5' end of the mitochondrial 16S RNA (16S mtrRNA). The transcript contains a stem-loop structure and is expressed in human proliferating cells but not in resting cells. Here, we demonstrate that, in addition to this transcript, normal human proliferating cells in culture express 2 antisense mitochondrial transcripts. These transcripts also contain stem-loop structures but strikingly they are down-regulated in tumor cell lines and tumor cells present in 17 different tumor types. The differential expression of these transcripts distinguishes normal from tumor cells and might contribute a unique vision on cancer biology and diagnostics.
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