The inhibition of keto acid oxidation by pyocyanine
1957
Campbell, J. J. R. | MacQuillan, A. M. | Eagles, B. A. | Smith, R. A.
When tested against Pseudomonas fluorescens, pyocyanine was found to stop the oxidation of a number of substrates at the keto acid level. This inhibition could be reversed by the addition of divalent cations. Of these, magnesium was most effective. The pigment was found to be similarly effective against the oxidations of Proteus vulgaris. Whole cells of Escherichia coli were not affected by the dye, whereas cell extracts were, indicating that the dye did not penetrate the cell membrane.
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