Immunomodulatory effect of dietary brewer’s yeast extract in Sander lucioperca juveniles against the challenge of Aeromonas salmonicida
2013
Jarmołowicz, Sylwia | Zakęś, Zdzisław | Siwicki, Andrzej | Terech-Majewska, Elżbieta | Kowalska, Agata | Partyka, Konrad | Hopko, Marek
The present study examined the influence of extract obtained from the interior of cells of yeast, Saccharomyces cerevisiae (NuProA[registered trademark]), on the growth, proximate composition, nonspecific cellular and humoral defense mechanisms, and protection against furunculosis in pikeperch (Sander lucioperca). It was noted that eight weeks of supplementation with 40 g of NuProA[registered trademark] kg-1 feed (containing approximately 0.22 % exogenic nucleotides) enhanced pikeperch innate immunity. Increased serum lysozyme activity and total Ig levels (P < 0.05) were noted in the NuProA[registered trademark]-fed group, which indicated the activation of nonspecific humoral defense mechanisms. Brewer's yeast extract also stimulated nonspecific cellular defense mechanisms as indicated by the increased metabolic activity of blood phagocytes and pronephric macrophages, and in the increased intracellular killing activity of phagocytes and proliferative responses of T and B lymphocytes (P < 0.05). Additionally, reduced mortality (15 %) after the in vivo challenge with pathogenic Aeromonas salmonicida suggested that NuProA[registered trademark] activated nonspecific protection against furunculosis in pikeperch. The experimental feed did not have a significant impact on the growth or proximate composition of the fish (P > 0.05).
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