Effect of heparin on hemagglutination by pseudorabies virus

Ohashi, S.; Inaba, Y.; Kataoka, J.; Tetsu, N.; Shibata, I.; Asagi, M.

Effect of heparin on hemagglutination by pseudorabies virus

1993

Heparin inhibited hemagglutination (HA) by pseudorabies virus (PRV), but not HA by Akabane virus, bovine adenovirus type 7, Fukuoka virus, Getah virus, Japanese encephalitis virus, and parainfluenza virus type 3 belonging to the families Bunyaviridae, Adenoviridae, Rhabdoviridae, Togaviridae, Flaviviidae, and Paramyxoviridae, respectively. The minimal inhibitory concentration of heparin required to inhibit 8 HA U of PRV ranged from 0.005 to 0.01 U/ml. Mouse erythrocytes failed to combine with the HA inhibitory factor of heparin. On the other hand, mouse erythrocytes treated with heparinase had greatly reduced agglutinability by PRV. Virus-heparin complex formation could be observed by sedimenting heparin with the virus particles.

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AGROVOC Keywords

akabane virus animals bovine adenovirus erythrocytes erythrocytes getah virus hemagglutination tests heparin heparin japanese encephalitis virus metabolism mice mice parainfluenza virus pharmacology rhabdoviridae temperature viruses

Bibliographic information

Published in

American journal of veterinary research

Volume 54 Issue 1 Pagination 99 - 102 ISSN 0002-9645

Other Subjects

Akabane orthobunyavirus; Suid alphaherpesvirus 1; Herpesvirus 1; Suid; Hemagglutination; Polysaccharide-lyases; Suid herpesvirus 1; Veterinary; Hemagglutination inhibition tests; Drug effects; Heparin lyase

Language

English

Note

2019-12-04

Type

Text; Journal Article

In AGRIS since: 2024-02-28

Format: MODS

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