Serum and tissue cage fluid concentrations of ciprofloxacin after oral administration of the drug to healthy dogs

Walker, R.D.; Stein, G.E.; Hauptman, J.G.; MacDonald, K.H.; Budsberg, S.C.; Rosser, E.J. Jr

Serum and tissue cage fluid concentrations of ciprofloxacin after oral administration of the drug to healthy dogs

1990

Ciprofloxacin, a fluoroquinolone antimicrobial agent, was administered orally to 4 healthy dogs at dosage of approximately 11 and 23 mg/kg of body weight, every 12 hours for 4 days, with a 4-week interval between dosing regimens. Serum and tissue cage fluid (TCF) concentrations of ciprofloxacin were measured after the first and seventh dose of each dosing regimen. The peak concentration was greatest in the serum after multiple doses of 23 mg/kg (mean +/- SEM; 5.68 +/- 0.54 micrograms/ml) and least in the TCF after a single dose of 11 mg/kg (0.43 +/- 0.54 micrograms/ml ml). The time to peak concentration was not influenced by multiple dosing or drug dose, but was longer for TCF (6.41 +/- 0.52 hour) than for serum (1.53 +/- 0.52 hour). Accumulation of ciprofloxacin was reflected by the area under the concentration curve from 0 to 12 hours after administration (AUC 0 leads to 12). The AUC 0 leads to 12 was greatest in the serum after multiple doses of 23 mg/kg (31.95 +/- 1.90 micrograms.h/ml) and least in the TCF after a single dose of 11 mg/kg (3.87 +/- 1.90 micrograms.h/ml). The elimination half-life was not influenced by multiple dosing or dose concentration, but was greater for TCF (14.59 +/- 1.91 hours) than for serum (5.14 +/- 1.91 hours). The percentage of TCF penetration (AUCTCF/AUCserum) was greater after multiple doses (95.76 +/- 6.79%) than after a single dose (55.55 +/- 6.79%) and was not different between doses of 11 and 23 mg/kg. Both dosing regimens of ciprofloxacin resulted in continuous serum and TCF concentrations > 90% of the minimal inhibitory concentration for the aerobic and facultative anaerobic clinical isolates tested, including Pseudomonas aeruginosa.

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AGROVOC Keywords

administration animals antimicrobial agents bacteria blood blood serum body fluids ciprofloxacin dogs dogs inhibition interstitial environment metabolism microbiology pharmacokinetics pharmacology skin diseases

Bibliographic information

Published in

American journal of veterinary research

Volume 51 Issue 6 Pagination 896 - 900 ISSN 0002-9645

Other Subjects

Time factors; Administration & dosage; Veterinary; Drug administration schedule; Catheters; Indwelling; Tissues; Anti-infective agents; Oral; Microbial sensitivity tests; Bacteriological techniques; Female; Half-life; Male; Minimal inhibitory concentrations

Language

English

Note

2019-12-04

Type

Journal Article; Text

In AGRIS since: 2024-02-28

Format: MODS

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