jpHMM at GOBICS: a web server to detect genomic recombinations in HIV-1
2006
Zhang, Ming | Schultz, Anne-Kathrin | Calef, Charles | Kuiken, Carla | Leitner, Thomas | Korber, Bette | Morgenstern, Burkhard | Stanke, Mario
Detecting recombinations in the genome sequence of human immunodeficiency virus (HIV-1) is crucial for epidemiological studies and for vaccine development. Herein, we present a web server for subtyping and localization of phylogenetic breakpoints in HIV-1. Our software is based on a jumping profile Hidden Markov Model (jpHMM), a probabilistic generalization of the jumping-alignment approach proposed by Spang et al. The input data for our server is a partial or complete genome sequence from HIV-1; our tool assigns regions of the input sequence to known subtypes of HIV-1 and predicts phylogenetic breakpoints. jpHMM is available online at http://jphmm.gobics.de/.
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