Visceral adipose tissue accumulation, secretory phospholipase A2-IIA and atherogenecity of LDL
2006
Paradis, M.E. | Hogue, M.O. | Mauger, J.F. | Couillard, C. | Couture, P. | Bergeron, N. | Lamarche, B.
Objective: The aim of the present study was to investigate the combined impact of visceral adipose tissue (VAT) and secretory group IIA phospholipase A2 (sPLA2-IIA) concentrations on the atherogenicity of low-density lipoprotein (LDL) particles among men. Subjects: Analyses were conducted in 74 mid-obese healthy men (age: (means.d.) 37.911.7 years). Methods: Plasma levels of sPLA2-IIA were measured with a commercial ELISA and VAT levels were assessed by computed tomography. Distinct subpopulations of LDL particles were characterized from whole plasma using nondenaturating 2-16% gradient gel electrophoresis. Results: Data indicated that plasma sPLA2-IIA levels were approximately 29% (P=0.007) higher among men characterized by a higher accumulation of VAT (>142 vs < = 142 cm2). Men having high plasma sPLA2-IIA levels (> = 127.2 ng/dl, the median value), were characterized by higher levels of plasma cholesterol (C) and apolipoprotein (apo) B, LDL-C, LDL-apoB, oxidized LDL (OxLDL) and by smaller LDL particles compared to men with sPLA2-IIA<127.2 ng/dl. Multiple regression analyses showed that plasma triglycerides and sPLA2-IIA levels explained 22.7 and 11.8% of the variance in LDL peak particle size, respectively. Levels of VAT and of sPLA2-IIA were the strongest correlates of OxLDL levels explaining, respectively, 15.0 and 5.5% of their variability. Conclusion: Both VAT and sPLA2-IIA levels modulate the atherogenecity of LDL by accounting for the reduction in their size and their susceptibility to oxidation.
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