Diuretic, natriuretic and hypotensive effects produced by Allium sativum (garlic) in anaesthetized dogs
1991
Pantoja, C.V. | Chiang, L.C. | Norris, B.C. | Concha, J.B.
Gastric administration of encapsuled garlic powder to anaesthetized dogs induced dose-dependent (2.5 to 15 mg/kg) natriuretic and diuretic responses which reached maximum 30-40 min after garlic administration and decreased to basal levels after 100-150 min. A simultaneous decrease in arterial blood pressure was observed which continued past the 250 min-mark. High garlic doses (15 and 20 mg/kg) provoked bradycardia and T-wave inversion during the first 10-15 min of the experiment with recordings returning to normal and staying normal throughout the remainder of the experiment.
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