The definition, source, manifestation and assessment of unintended effects in genetically modified plants
2008
Deng, Ping-Jian | Zhou, Xiang-Yang | Yang, Dong-Yan | Hou, Hong-Li | Yang, Xiao-Ke | Li, Yong-Hong | Yang, Yong-Cun | Wang, Xue-Lin | Fang, Shi-Song | Wu, Shui-Qing | Liu, Jin
At present, there is consensus among many relevant international agencies that unintended effects should be paid particular attention in the process of edible safety assessment of genetically modified plants (GMPs) and their products, especially in regard to some long-term and potential food safety issues. However, with respect to the current risk assessment of GMPs, serious dissension on the apprehension of unintended effects exists. The present paper interprets and systematically analyses this dissension in order to review development on the definition, source and manifestation of unintended effects in GMPs. First, differences in the various concepts of unintended effect are discussed and compared. Then the mechanisms whereby unintended effects may arise during GMP breeding are analysed and the main unexpected variation manifestations in GMPs are presented. With regard to the safety assessment of unintended effects in GMPs, the current evaluation strategy, detection methods and several assessment cases are expounded. In addition, the unique assessment standard for unintended effects in GMPs in China is outlined.
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