Antiulcerative potential of sweet potato (Ipomoea batatas) against aspirin-induced gastric ulcers in a rabbit model
2022
Pāshā, ʻImrān | Arshad, Ammara | Ahmed, Farah | ʻAlī, Raz̤ā
Sweet potato (Ipomoea batatas) is accredited as a functional food because of its nutraceutical compounds. These dietary components may help heal lesions and ulcer scars in the stomach. This research was designed to examine the antioxidant and antiulcerative potential of sweet potato (red skin, white flesh) against aspirin-induced gastric ulcers in a rabbit model. Sweet potato samples were analyzed for in vitro analysis, such as 2,2-diphenyl-1-picrylhydrazyl assay, total phenolic content, and total flavonoid content. In a bioefficacy study, rabbits were divided into five groups (n = 6) in which G₀ received the standard diet only, G₁ 150 mg/kg aspirin, G₂ 20 mg/kg omeprazole, G₃ 1000 mg/kg aqueous extract of sweet potato, and G₄ 1000 mg/kg ethanolic extract of sweet potato. After completion of the trial, the animals were decapitated and examined for antiulcer parameters, serum analysis, and hematologic parameters. The mean values for 2,2-diphenyl-1-picrylhydrazyl, total phenolic content, and total flavonoid content were 57%, 927 mg gallic acid equivalent/100 g, and 1901 µg quercetin equivalent/g, respectively. The values for gastric volume, acid output, ulcer scores and index, total oxidant status, white blood cell count, and lymphocyte count were increased significantly (P < 0.05) for the positive control group compared with G₂, G₃, and G₄. Gastric pH and body weight at the end of the experiment were significantly reduced for the positive control group (P < 0.05) compared with G₂, G₃, and G₄. Histology test results of gastric tissues in G₁ depicted severe epithelial damage compared with G₂, G₃, and G₄. The results for the antiulcer parameters ascertained the antiulcer activity of sweet potato in aspirin-induced gastric ulcer models.
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