Rotavirus infections with multiple emerging genotypes in Sri Lanka
2010
Ahmed, Kamruddin | Batuwanthudawe, Ranjith | Chandrasena, T. G. A Nilmini | Mitui, Marcelo Takahiro | Rajindrajith, Shaman | Galagoda, Geethani | Pun, Sher Bahadur | Uchida, Ryuichi | Kunii, Osamu | Moji, Kazuhiko | Abeysinghe, Nihal | Nishizono, Akira | Nakagomi, Osamu
Rotavirus diarrhea is an important cause of child mortality in developing countries, but studies on this diarrhea are scarce in Sri Lanka. A prospective study conducted in Sri Lanka on rotavirus infection among children in a hospital setting (n = 611) versus children residing in tsunami camps (n = 52) showed that prevalence of rotavirus infection was comparable, 21.9 and 20%, respectively. The hospital and camps were located in different districts. Analysis of the genotypes of 122 rotaviruses from the hospital and 12 from the camps indicated that G9P[8] was associated with 35 and 33%; G12P[8/nt] with 14.7 and 33%; G3P[8/4/nt] with 17 and 8% and G1P[8/4] with 6.5 and 16.7%. Rotaviruses with G2P[8/4/6] and G4P[8/4] were hospital-associated only, and some rotaviruses (9 and 8% from the hospital and the camps, respectively) were G- and P-nontypable. We conclude from the present study that multiple emerging genotypes were prevalent in Sri Lanka, and children in camps were at risk of developing diarrhea due to rotaviruses.
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