Expression of fibronectin and its integrin receptor alpha 5 beta 1 in canine mammary tumours
1994
Pena, L. | Nieto, A. | Perez Alenza, M.D. | Fernandez, Aurelio Rodriguez | Sanchez, M.A. | Castano, M.
Fibronectin and its integrin receptor alpha 5 beta 1 (a5b1) were studied by immunohistochemical methods in five normal canine mammary glands, four dysplastic glands and 18 mammary tumours. The aim of the study was to evaluate the possible changes in the a5b1 integrin receptor and its ligand fibronectin in relation to the metastatic capacity of canine mammary neoplasms. The immunostaining of a5b1 was very uniform in the hyperplastic glands but uneven in the mammary tumours. The expression of a5 and b1 was diminished in metastatic tumours but there were some a5-positive cells with pronounced features of malignancy and immaturity. Stromal fibronectin was increased in most cases and cytoplasmic staining of fibronectin was observed in epithelial and myoepithelial cells in mammary neoplasms but not in normal or dysplastic mammary tissue. There was no relationship between the content of a5b1 and the expression of fibronectin in canine mammary tumours.
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