Dietary fat saturation affects hepatocyte insulin binding and glucose metabolism in BHE rats
1991
Pan, J.S. | Berdanier, C.D.
The influence of feeding 6% hydrogenated coconut oil, corn oil or menhaden off on hepatocyte insulin binding, receptor number and glucose use was studied. Hepatocytes isolated from rats fed menhaden oil had a significantly greater affinity for insulin than hepatocytes from rats fed hydrogenated coconut off. Glucose use was not influenced by diet; uniformly labeled glucose was metabolized to CO2 or to lipid similarly in cells isolated from rats fed the three oils. Thus, dietary fat type in a low fat diet influenced events at the plasma membrane without influencing intracellular events.
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