Enteric hyperoxaluria
1979
Hoffmann, Alan F.
Enteric hyperoxaluria, a relatively new syndrome discovered in 1972 at the Mayo Clinic, is characterized by excessive oxalate excretion in urine and absorption of abnormal amounts of dietary oxalate. It is frequently seen in patients with inflammatory disease of the small intestine. Hyperabsorption of oxalate is thought to be connected with poor absorption of fatty acids and bile acid malabsorption. Therapy involves reduction of dietary oxalate, but dietary management is not always effective, suggesting the endogenous production of oxalate from a still-unknown source. Ascorbic acid may be metabolized to oxalate, so vitamin C intake should be limited.
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