Comparison of lipid-walled microcapsules and lipid spray beads for the delivery of water-soluble, low-molecular-weight materials to aquatic animals
1998
Langdon, C.J. | Buchal, M.A.
Microparticles (< 40 micrometer diameter) composed of 600 mg g-1 tripalmitin/400 mg g-1 fish oil were used to encapsulate the low-molecular-weight (mol. wt 460) antibiotic oxytetracycline in the form of either oxytetracycline hydrochloride (OTC.HCl) or oxytetracycline hemicalcium salt (OTC.HEM). Dry, finely ground particles of core material were encapsulated in spray heads. Dissolved core material was encapsulated in lipid-walled microcapsules. Oxytetracycline (OTC) was most efficiently delivered (approximately equal to 46.5 mg g-1 lipid after 24 h suspension in seawater) as a hemicalcium salt in spray beads. Lipid-walled microcapsules were most efficient for delivering OTC (approximately equal to 8.7 mg g-1 lipid) as OTC.HCl dissolved in 0.2 M MCl at a concentration of 300 mg mL-1. Spray beads containing OTC.HEM were very stable over 1 month in storage. Lipid-walled microcapsules containing aqueous OTC.HCl lost approximately equal to 30% of their core material during storage. Freeze-drying of both microparticle types did not improve storage of spray beads, but showed promise for reducing leakage from lipid-walled microcapsules during storage and delivery to suspension feeders.
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