Effect of dietary Pinus densiflora bark extract on nutrient utilization and intestinal health in weaned piglets
2022
Kim, Kum-Chol | Han, Myong-Hun | Pak, Myong-Nam | Sin, Jo-Il | Ri, Kwang-Chol | Pak, Sŏng-sik | Ri, Jong-Ho | Pak, Chol-Jin | Won, Kwang-Yon
Pinus densiflora bark extracts (PBE) has been widely used in health care medicine and animal husbandry by its beneficial physiological functions such as antioxidant activity, anti-inflammatory, antibacterial and antiviral activity. The study aimed to investigate the effect of dietary level of PBE on diarrhea rate, nutrient digestibility and intestinal health in weaned piglets. 120 crossbreed pigs were divided randomly into 4 treatment groups (0, 100, 200, 300 mg/kg PBE, respectively), with 3 replicates per treatment and 10 piglets per replicate. The experiment lasted for 28 d. Dietary supplementation with PBE significantly decreased diarrhea rate and diarrhea index (p < 0.0001). The groups supplemented with dietary PBE showed significant decrease in total tract apparent digestibility (TTAD) of crude protein (CP), gross energy (GE) and ether extracts (EE) (p < 0.05), while there was no significant effect of TTAD on dry matter (DM). Interestingly, the trypsin was not affected by dietary PBE, and the lipase and amylase activities decreased significantly in pigs fed diets supplemented with PBE (p < 0.05). The levels of total protein and glucose in serum were significantly increased by adding PBE in diets (p < 0.05), and levels of diamine oxidase (DAO) and endotoxin in serum were reduced by PBE supplementation (p < 0.05). The mRNA expression levels of tight junction proteins in the jejunum were significantly up-regulated compared to control. This study revealed that PBE supplementation decreased nutrient utilization and decreased diarrhea rate with improvement of the intestinal health in weaned piglets, and suggested appropriate dietary concentration of PBE supplementation would be 200 mg/kg.
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