Under what conditions is it possible to produce pigs without using antimicrobials?

Antimicrobials are commonly used in pig production to control bacterial infections. However, there is increasing pressure from supermarkets and consumers and other sectors to reduce or eliminate the use of antimicrobials in animal agriculture. Banning the use of antimicrobials in some countries has led to increased disease and welfare problems, so it is important to know under what conditions pigs can be produced without the use of antimicrobials. In this review, practices that can prevent disease, and therefore reduce the need for antimicrobials were researched from published experimental challenge trials, field studies and risk factor analyses. Disease prevention practices were examined from pathogen survival and transmission studies, vaccine and disinfectant efficacy studies and nutrition trials. From these studies we collated the important practices that manage or prevent disease and improve pig health. We also reviewed new diagnostic assays and technologies to better monitor the pig and its environment at the herd level. Many of the conditions necessary to produce pigs without antimicrobials have been known and understood for a long time. The application of high standards of biosecurity and hygiene is crucial for creating the conditions for reduction of antimicrobial use. Factors important in preventing disease include eradication or elimination of pathogens, minimising mixing of pigs, cleaning and disinfection of pens and sheds, ventilation to improve air quality, reducing stocking density and eliminating potential vectors of disease. Improving the health of pigs also relies on vaccination and improved consistency of nutrition. The development of diagnostic technologies that correlate with disease and production will enable the detection of potential disease problems at the individual or herd level before disease outbreaks occur and before antimicrobials are needed. The development of vaccination technologies for prevention of disease and diagnostic technologies that can be used on-farm to predict disease outbreaks are integral to safely moving towards antimicrobial-free pork. Pig production without the use of antimicrobials is not simply a matter of substituting conventional antimicrobials with alternative antimicrobial substances and expecting the same result. Any move to antimicrobial-free production requires an acknowledgement that pig production costs may increase and that many pig production practices must change. Such changes must also ensure that animal welfare and food safety and quality standards are maintained or improved, and that reliable markets for the product are found. This paper does not seek to argue the science or opinion of reasons behind the desire to reduce antimicrobial use in animal agriculture, but rather discuss the circumstances under which reduction or elimination of antimicrobial use in pig production is possible.