Characterization of a Humanized Monoclonal Antibody Recognizing Clumping Factor A Expressed by Staphylococcus aureus
2005
Domanski, Paul J. | Patel, Pratiksha R. | Bayer, Arnold S. | Zhang, Li | Hall, Andrea E. | Syribeys, Peter J. | Gorovits, Elena L. | Bryant, Dawn | Vernachio, John H. | Hutchins, Jeff T. | Patti, Joseph M.
We report the humanization and characterization of monoclonal antibody (MAb) T1-2 or tefibazumab, a monoclonal antibody that recognizes clumping factor A expressed on the surface of Staphylococcus aureus. We demonstrate that the binding kinetics of MAb T1-2 is indistinguishable compared to that of its murine parent. Furthermore, MAb T1-2 is shown to enhance the opsonophagocytic uptake of ClfA-coated latex beads, protect against an intravenous challenge in a prophylactic model of rabbit infective endocarditis, and enhance the efficacy of vancomycin therapy in a therapeutic model of established infective endocarditis.
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