A new ent-kaurane diterpene from Euphorbia stracheyi Boiss
2017
Liu, Tie | Liang, Qian | Xiong, Na-Na | Dai, Lin-Feng | Wang, Jun-Ming | Ji, Xiao-Hui | Xu, Wen-Hui
The chemical investigation of whole plants Euphorbia stracheyi Boiss from China led to the isolation of one new ent -kaurane diterpene, ent -Kaurane-16 β ,17,19-triol-3-one (1), along with three known ent -kaurane diterpenoids (2 – 4) as ent -Kaurane-3 α ,16 β ,17-triol (2)， ent -16 S ,17-dihydroxy-kaurane-3-one (3) and ent -3 S ,16 S ,17-trihydroxy-kaurane-2-one (4). Their structures were elucidated by extensive spectroscopic analyses including 1D, 2D NMR, HR-ESI-MS, and by comparison with the literature. Compound 2 was a new natural product and firstly isolated from nature, while compounds (3 – 4) were isolated from E. stracheyi for the first time. All isolated compounds (1 – 4) were evaluated for their cytotoxic activities against five human cancer cell lines (including A-549, SMMC-7721, HL-60, MCF-7 and SW-480).
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