Target-oriented inhibitors of the late stages of trichothecene biosynthesis. 1. Design, syntheses, and proof of structures of putative inhibitors
1992
Zamir, L.O. | Nikolakakis, A. | Sauriol, F.
Fusarium spp. produce several toxic secondary metabolites (zearalenone, moniliformins, fusarinins, trichothecenes, etc.). Moldy corn toxicosis has been associated with trichothecenes. We have focused in this study on Fusarium culmorum, which produces the trichothecenes 3-acetyldeoxynivalenol and sambucinol as major metabolites. We have designed and synthesized putative inhibitors based on the knowledge of the biosynthetic pathway of trichothecenes. A fluorine group was introduced at a strategic position on the trichothecene moiety, or the epoxide at C12-C13 was eliminated. The structures of these new compounds were rigorously characterized by spectroscopic techniques.
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