Structurally rigidified cobalt bis(dicarbollide) derivatives, a chiral platform for labelling of biomolecules and new materials
2022
El Anwar, Suzan | Pazderová, Lucia | Bavol, Dmytro | Bakardjiev, Mário | Růžičková, Zdeňka | Horáček, Ondřej | Fojt, Lukáš | Kučera, Radim | Grűner, Bohumír
We report the difunctional modification of an anionic cobalta bis(dicarbollide)(1⁻) cluster with a B(8,8′)-oxygen bridging unit that provides structural rigidity and an organic alkylazide substituent(s) on the carbon atoms of the metallacarborane cage. These ions present a good binding motif for incorporation into organic molecules using Huisgen-Sharpless (2+3) cycloaddition reactions. In addition, the compounds are chiral, as verified by separation of enantiomers using HPLC on chiral stationary phases (CSPs) and provide a high electrochemical peak in the window located outside of typical signals of biomolecules.
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