Surface modified halloysite nanotubes with different lumen diameters as drug carriers for cancer therapy
2021
Liao, Juan | Zifeiyu, | Tang, Aidong | Fu, Liangjie | Ouyang, Jing | Yang, Huaming
Paclitaxel (PTX) is successfully loaded by surface modification of distearoyl phosphoethanolamine (DSPE) on halloysite nanotubes (HNTs) with different inner lumen diameters. Drug loading of DSPE-HNTs-PTX attains 18.44% of DSPE content with a nearly complete release (near 100%) achieved. The anticancer efficacy (cell viability less than 52%) of DSPE-HNTs₁₅-PTX increased and is attributed to the lower interfacial energy both inside and outside the tubes that improves tube loading.
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