Genotoxicity potential of a new natural formicide
2012
Cotelle, Sylvie | Testolin, Renan C. | Foltête, Anne-Sophie | Bossardi-Rissardi, Georgiana | Silveira, Rosilene A. | Radetski, Claudemir M.
BACKGROUND, AIM, AND SCOPE: Assessment of environmental impacts from pesticide utilization should include genotoxicity studies, where the possible effects of mutagenic/genotoxic substances on individuals are assessed. In this study, the genotoxicity profile of the new formicide Macex® was evaluated with two genotoxicity tests, namely, the micronucleus test with mouse bone marrow and Vicia faba, and a mutagenicity test using the Ames Salmonella assay. MATERIALS AND METHODS: The bacterial reverse mutation test (Salmonella typhimurium strains TA97, TA98, TA100, TA102, and TA1535), the Vicia root tip and mouse micronucleus tests were conducted according to published protocols. RESULTS: In the range of the formicide Macex® concentrations tested from 0.06 to 1.0 g L−1 (or mgkg−1 in the mouse test), no genotoxicity was observed in the prokaryotic or eukaryotic test organisms. However, at Macex® concentrations of 0.5 g L−1 and above a significant decrease in the mitotic index (P ≤ 0.05) in the V. faba was observed. Micronucleus formation was likewise increased in the test organism at concentrations starting at 2.0 g L−1. CONCLUSIONS: These data allow us to classify this natural formicide preparation as a product with no geno-environmental-impact when applied at recommended concentrations.
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