The reproducibility of the modified relative dose response (MRDR) assay in health individuals over time and its comparison with conjunctival impression cytology (CIC)
1991
Tanumihardjo, S.A. | Olson, J.A.
The modified relative dose response (MRDR) assay is a minimally invasive method of detecting marginal vitamin A status. In the present study, the MRDR assay was performed four times in six well-nourished adults and in one male five-year-old child over a seven-month period. In all instances, assay ratios of dehydroretinol (DR) to retinol (R) were < 0.03, the tentative cutoff value of 'normal' for the MRDR assay in humans. The mean ratio for all time points for all individuals was 0.015 +/- 0.005, with a mean coefficient of variation of 27 +/- 13%. In a related experiment, both MRDR and conjunctival impression cytology (CIC) tests were conducted on nine adults and the same male child. All DR/R ratios were less than or equal to 0.021, and all CIC specimens were normal. Thus, the DR/R ratio in well-nourished individuals, although showing some variation, does not oscillate between abnormal and normal responses. Furthermore, the DR/R ratios and CIC patterns were fully concordant.
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