Effects of maternal dietary protein content on cerebral ketone body-metabolizing enzymes in the progeny of rats
1991
John, J. | Patel, M.S. | Telang, S.D.
The effect of maternal dietary protein content on blood glucose and ketone bodies and on cerebral ketone body-metabolizing enzymes in the rat progeny was investigated. four different diets having either 15.5% (adequate) or 5.4% (low) calories from protein with 12.2% or 47.1% calories from fat (AP-HC, adequate protein-high carbohydrate die; AP-HF, adequate protein-high fat diet; LP-HC, low protein-high carbohydrate diet; and LP-HF, low protein-high fat diet) were fed to females starting at 2 weeks prior to mating and continued throughout pregnancy and lactation. Compared to the pups of mothers on the diets with adequate levels of protein, the pups of mothers on the low protei diets had stunted growth and also had significant reductions in brain weight gains in the postnatal period. Undernutrition due to maternal low protein diets (LP-HC and LP-HF) resulted in significantly higher activities of brain D-3-hydroxybutarate dehydrogenase and 3-oxoacid CoA-transferase in the pups on day 18 than the corresponding values for pups in adequate protein (AP-HC and AP-HF) groups. The results show that the reduction in protein content in maternal diet increased the activity levels of cerebral ketone body-metabolizing enzymes in suckling rats.
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