Stability of 0.5% cidofovir stored under various conditions for up to 6 months
2010
Stiles, Jean | Gwin, Wilson | Pogranichniy, Roman
To evaluate the effect of time, temperature and storage vial material on the antiviral activity of 0.5% cidofovir solution. Commercial 7.5% cidofovir solution for injection was diluted with normal saline to a 0.5% concentration. Aliquots were stored in plastic and glass vials at 4, -20, and -80 °C for 30, 60, 120, and 180 days. Antiviral activity against feline herpesvirus was evaluated in a virus titration assay at time zero (baseline) and at each subsequent time point. Cidofovir caused a fourfold log reduction in virus titer at baseline and at each time point and for each storage condition (P < 0.001). 0.5% cidofovir demonstrated stable antiviral activity when stored for up to 6 months in glass or plastic, at 4, -20, and -80 °C.
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