A Scalable Method for Regioselective 3-Acylation of 2-Substituted Indoles under Basic Conditions
2015
Johansson, Henrik | Urruticoechea, Andoni | Larsen, Inna | Sejer Pedersen, Daniel
Privileged structures such as 2-arylindoles are recurrent molecular scaffolds in bioactive molecules. We here present an operationally simple, high yielding and scalable method for regioselective 3-acylation of 2-substituted indoles under basic conditions using functionalized acid chlorides. The method shows good tolerance to both electron-withdrawing and donating substituents on the indole scaffold and gives ready access to a variety of functionalized 3-acylindole building blocks suited for further derivatization.
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