The association between short-term exposure to extremely high level of ambient fine particulate matter and blood pressure: a panel study in Beijing, China
2020
Xu, Ning | Lv, Xifang | Yu, Chuanchuan | Guo, Yafei | Zhang, Kexing | Wang, Qiang
High blood pressure (BP) is known as the main determinant of high cerebrovascular disease levels in China. Many studies discovered the associations between short-term exposure to PM₂.₅ and BP, while most of those focused on low or medium PM₂.₅ concentration. The aim of this study was to reveal the association between extremely high level ambient PM₂.₅ exposure and BP. We conducted a repeated-measures panel study in Beijing, China, during December 1, 2016 to December 28, 2016. BP was monitored daily for all 133 participants. Daily concentration of PM₂.₅ was obtained from local monitoring sites. A linear mixed-effect model combined with the distributed lag non-linear model was used to evaluate the associations between PM₂.₅ and daily variations in BP. This study showed short-term exposure to PM₂.₅ that was significantly associated with increased DBP (on lags of 0–8 days, Beta = 0.12, 95% confidence interval 0.04, 0.20). The single day effect of PM₂.₅ on DBP had a 2-day lag, and the cumulative effect lags 5 days. The effects of PM₂.₅ on SBP and DBP on hypertensive adults were significant. The cumulative effect of PM₂.₅ on SBP and DBP had 2 rapidly increasing periods in hypertensive adults: lags of 0–2 days and lags of 0–7 days to lags of 0–11 days. Our study revealed that short-term exposure in the extreme high level of ambient PM₂.₅ may increase BP among adults. Hypertensive adults may more sensitive than normotensive adults. The periodic high concentration of ambient PM₂.₅ might magnify the effect of PM₂.₅ on BP increase.
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