Conformational and functional properties of peptides covering the intersubunit region of influenza virus hemagglutinin
1992
HOLLÃSI, Miklos | ISMAIL, Ashraf A. | Mantsch, Henry H. | PENKE, Botond | VARADI, Istvan G. | TOTH, Gabor K. | LACZKÃ, Ilona | Kurucz, István | Nagy, Zoltán | Fasman, Gerald D. | RAJNAVÃLGYI, Eva
The functionally active part of influenza virus hemagglutinin was investigated through the synthesis of a series of peptides representing different parts of the intersubunit region. Secondary structure prediction, circular dichroism and Fourier transform infrared spectroscopic studies were undertaken to investigate the secondary structure of these peptides. The peptide fragments were found to adopt multiple conformations, depending on their concentration in solution, the presence of the nonâionic detergent octylâβâdâglucoside and the polarity of the solvent. The results of biological studies with these peptide fragments are discussed in relation to their conformation, as inferred from the spectroscopic analysis.
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