Diphenyl diselenide attenuates hepatic and hematologic toxicity induced by chlorpyrifos acute exposure in rats
2012
Acker, Carmine Inês | Souza, Ana Cristina Guerra | dos Santos, Maurício Portella | Mazzanti, Cinthia Melazzo | Nogueira, Cristina Wayne
PURPOSE: In this study, we investigated the effect of diphenyl diselenide [(PhSe)2] on chlorpyrifos (CPF)-induced hepatic and hematologic toxicity in rats. METHODS: Rats were pre-treated with (PhSe)2 (5 mg/kg) via the oral route (oral gavage) once a day for 7 days. On the eighth and ninth days, rats were treated with (PhSe)2 (5 mg/kg) 30 min prior to CPF (50 mg/kg, by subcutaneous route). The aspartate aminotransferase, alanine aminotransferase, and lactate dehydrogenase activities were determined in plasma of rats. Lipid peroxidation, protein carbonyl, and non-protein thiol levels as well as catalase, superoxide dismutase, glutathione peroxidase, glutathione reductase, and gluthatione S-transferase activities were determined in livers of rats. Hematological parameters were also determined. RESULTS: The results showed that CPF caused hepatic oxidative damage, as demonstrated by an increase in lipid peroxidation and protein carbonyl levels which was associated with a decrease in antioxidant defenses. CPF exposure caused a reduction in the leukocyte, indicating hematologic toxicity. (PhSe)2 was effective in attenuating these toxic effects caused by CPF exposure in rats. CONCLUSIONS: The results indicated that (PhSe)2 was effective in protecting the hepatic and hematologic toxicity induced by acute CPF exposure in rats.
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