Ancient pathways programmed by small RNAs

Zamore, P.D.

Ancient pathways programmed by small RNAs

2002

Zamore, P.D.

Double-stranded RNA can now be used in a wide variety of eukaryotes to suppress the expression of virtually any gene, allowing the rapid analysis of that gene's function, a technique known as RNA interference. But how cells use the information in double-stranded RNA to suppress gene expression and why they contain the machinery to do so remain the subjects of intense scrutiny. Current evidence suggests that RNA interference and other "RNA silencing" phenomena reflect an elaborate cellular apparatus that eliminates abundant but defective messenger RNAs and defends against molecular parasites such as transposons and viruses.

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AGROVOC Keywords

animals gene expression gene silencing genes genetics humans mechanism of action metabolism plant plant diseases plants rna rna rna rna rna rna transcription transgenes virus diseases

Bibliographic information

Published in

Science

Volume 296 Issue 5571 Pagination 1265 - 1269 ISSN 0036-8075

Other Subjects

Prevention & control; Ribonucleoproteins; Rna silencing; Dna transposable elements; Ribonuclease iii; Virus physiological phenomena; Small interfering; Double-stranded; Rna interference; Double-stranded rna; Endoribonucleases; Double stranded ran; Untranslated; Messenger; Antisense; Rna-dependent rna polymerase; Genetic; Small nuclear rna

Language

English

Note

Special section: rna silencing and noncoding dna.

Type

Journal Article; Text

In AGRIS since: 2024-02-28

Format: MODS

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Ancient pathways programmed by small RNAs

2002

AGROVOC Keywords

Bibliographic information