Evaluation of a synthetic C34 trimer of HIV-1 gp41 as AIDS vaccines
2012
Hashimoto, Chie | Nomura, Wataru | Ohya, Aki | Urano, Emiko | Miyauchi, Kosuke | Narumi, Tetsuo | Aikawa, Haruo | Komano, Jun A. | Yamamoto, Naoki | Tamamura, Hirokazu
An artificial antigen forming the C34 trimeric structure targeting membrane-fusion mechanism of HIV-1 has been evaluated as an HIV vaccine. The C34 trimeric molecule was previously designed and synthesized using a novel template with C3-symmetric linkers by us. The antiserum produced by immunization of the C34 trimeric form antigen showed 23-fold higher binding affinity for the C34 trimer than for the C34 monomer and showed significant neutralizing activity. The present results suggest effective strategies of the design of HIV vaccines and anti-HIV agents based on the native structure mimic of proteins targeting dynamic supramolecular mechanisms in HIV fusion.
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