High protein diets and bone homeostasis
1981
The effects of excess dietary protein on calcium metabolism have been investigated in several studies which show a negative calcium balance. This seems to be due to the calciuric properties of different proteins, possibly related to the sulfur amino acid content. The oxidation of excess methionine and cystine produces an increase in metabolic acid as sulfate. This has been shown to be acutely calciuric in animals. In humans, urinary calcium increases as a result of a decrease in fractional renal tubular reabsorption of calcium and an increase in glomerular filtration rate. Another factor which may be related to bone homeostasis is calcium-phosphorus balance, since phosphorus intake usually relates to protein intake while calcium intake depends primarily on consumption of dairy foods.
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