WHO guidance on COVID-19 vaccine trial designs in the context of authorized COVID-19 vaccines and expanding global access: Ethical considerations
2022
Singh, Jerome Amir | Kochhar, Sonali | Wolff, Jonathan | Atuire, Caesar | Bhan, Anant | Emanuel, Ezekiel | Faden, Ruth | Ghimire, Prakash | Greco, Dirceu | Ho, W. Calvin | Moon, Suerie | Shamsi-Gooshki, Ehsan | Touré, Aissatou | Thomé, Beatriz | Smith, Maxwell J. | Upshur, Ross E.G.
While the degree of COVID-19 vaccine accessibility and uptake varies at both national and global levels, increasing vaccination coverage raises questions regarding the standard of prevention that ought to apply to different settings where COVID-19 vaccine trials are hosted. A WHO Expert Group has developed guidance on the ethical implications of conducting placebo-controlled trials in the context of expanding global COVID-19 vaccine coverage. The guidance also considers alternative trial designs to placebo controlled trials in the context of prototype vaccines, modified vaccines, and next generation vaccines.
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